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Activity Number:
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39
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Type:
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Invited
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Date/Time:
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Sunday, July 29, 2007 : 4:00 PM to 5:50 PM
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Sponsor:
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ENAR
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| Abstract - #308102 |
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Title:
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Interactions in Whole-Genome Association Studies
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Author(s):
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Josephine Hoh*+
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Companies:
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Yale University
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Address:
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60 College Street, New Haven, CT, 06510-3210,
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Keywords:
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genome-wide ; epistasis ; association
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Abstract:
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Whole genome association mapping has been proven to be efficient in searching susceptibility genes for human illnesses. Data in this type of studies are enormous. While association tests generally look for a main effect, interactions between loci (epistasis) also contribute to phenotypic variation. This presentation will focus on SNP interactions in disease association. Two-stage approach has been developed. We applied our methods to the real data containing 100K and 300K SNPs. At the first stage we directly screen interactions without main effects being specified. Based on the scales of relative risks, we identify those pairs of SNPs with cross-over responsive curves under all possible disease inheritance modes. At the second stage, we evaluate the significance of the interactions in disease association and also try to construct the hypothetical genetic networks.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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