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Activity Number:
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260
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Type:
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Invited
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Date/Time:
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Tuesday, July 31, 2007 : 10:30 AM to 12:20 PM
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Sponsor:
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Biometrics Section
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| Abstract - #308082 |
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Title:
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Multicenter Clinical Trials with Binary Outcomes and Random Effects for Centers: Sample Size Determination
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Author(s):
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Kathryn Chaloner*+
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Companies:
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The University of Iowa
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Address:
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Dept of Biotatistics, Dept of Statistics and Actuarial Science, Iowa City, IA, 52242,
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Keywords:
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Bayesian ; Clinical trial ; Sample Size
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Abstract:
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The question of choosing a sample size for a multi-center clinical trial where the analysis involves a binary response will be reviewed. A Bayesian hierarchical model is assumed. Centers are assumed to be exchangeable and so random effects for center are incorporated into the statistical analysis plan. Enrollment at each center is anticipated to be different, with some centers having much larger sample sizes than others. Of interest is not only to determine overall efficacy of an intervention, but also to require each center to demonstrate sufficient evidence of efficacy. Examples will be given, along with simulations to examine the properties of different designs. This work is joint with M. Katherine Cowles, Emine O. Bayman, Qian Cicci Shi and Lixun Zhang (University of Iowa).
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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