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Activity Number:
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223
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Type:
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Invited
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Date/Time:
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Tuesday, July 31, 2007 : 8:30 AM to 10:20 AM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #308010 |
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Title:
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Systematic Mining of a Large Gene Expression Database and Design of a Multi-Endpoint Diagnostic Device
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Author(s):
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Georges Natsoulis*+
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Companies:
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Datahooks, Inc.
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Address:
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256 Stanford Avenue, Kensington, CA, 94708,
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Keywords:
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data mining ; gene expression ; diagnostic device ; classification ; toxicity ; pharmacology
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Abstract:
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A contextual database was created to relate the physiological outcomes induced by diverse compounds to the gene expression patterns measured in the same animals. This database developed from in vivo treated rats provides the context and supporting data to accelerate accurate interpretation of mechanisms of toxicity and pharmacology of chemicals and drugs. To date, approximately 600 different compounds, including more than 400 FDA approved drugs, have been profiled in up to 7 different tissues of rats. We describe the systematic mining of the DrugMatrix database using a supervised classification approach and determine the set of all resolvable endpoints. We show that a relatively small number of genes are used in a large number of signatures and that a small set of genes is sufficient to rederive signatures for all the above end-points, suggesting the basis of a diagnostic device.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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