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Abstract:
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The National Children's Study (NCS) is a large-scale study that offers unique opportunities to evaluate relationships among multiple exposures and changes in susceptibility over life stages, and subsequent health and developmental outcomes. Exposure measures are selected based on Study hypotheses, and include chemical, physical, biological, and social environments. Given multiple hypotheses, these measures will be primary exposures in some instances and key covariates for others. Statistical and logistical considerations for exposure assessment designs and approaches will be discussed, including: integrating different types of exposure information, targeting assessments to key exposure pathways and locations, combining individual- and aggregate-level (e.g., community) information, and using nested case-control and other designs to minimize participant burden and costs.
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