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Activity Number: 362
Type: Invited
Date/Time: Wednesday, August 1, 2007 : 8:30 AM to 10:20 AM
Sponsor: Section on Teaching Statistics in the Health Sciences
Abstract - #307908
Title: Conditional AIC for Nonlinear Mixed Effects Models
Author(s): Florin Vaida*+
Companies: University of California, San Diego
Address: Division of Biostatistics, 9600 Gilman Drive, MC-0717, La Jolla, CA, 92093,
Keywords: effective degrees of freedom ; model selection
Abstract:

In this paper we propose a model selection criterion for nonlinear and generalized linear mixed-effects model (NLME, GLME). The conditional AIC of Vaida and Blanchard (2005) is extended to NLME, using an appropriate definition of the effective degrees of freedom of the model, rho. This rho was proposed for GLME by Lu, Hodges and Carlin (2006). The criterion approximates the conditional Akaike information and the goodness of the approximation depends on the degree of non-linearity of the model. The conditional AIC is useful when the purpose of the model is subject-specific rather than population-level prediction. We use the criterion for model selection in the analysis of data from an ongoing international study of acute HIV infection.


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Revised September, 2007