JSM Preliminary Online Program
This is the preliminary program for the 2007 Joint Statistical Meetings in Salt Lake City, Utah.

The views expressed here are those of the individual authors
and not necessarily those of the ASA or its board, officers, or staff.


Back to main JSM 2007 Program page

Activity Number: 120
Type: Invited
Date/Time: Monday, July 30, 2007 : 10:30 AM to 12:20 PM
Sponsor: Biometrics Section
Abstract - #307768
Title: Quantifying Protein: Reverse-Phase Protein Arrays
Author(s): Keith Baggerly*+
Companies: The University of Texas M.D. Anderson Cancer Center
Address: 1100 Holcombe Blvd, Unit 237, Houston, TX, 77030-3906,
Keywords: proteomics ; bioinformatics ; ELISA ; immunology ; preprocessing
Abstract:

Reverse-Phase Protein Arrays (RPPAs, aka protein lysate arrays, tissue lysate arrays, or lysate arrays) are recently developed tools for measuring protein expression levels in large numbers of samples. These assays are for the most part massively parallelized versions of enzyme-linked immunosorbent assays (ELISAs). In their massive parallelization, these assays are similar to cDNA microarrays (for mRNA) and CGH assays (for DNA). However, while those assays make thousands of measurements on a single sample ("forward-phase"), RPPAs measure one thing on hundreds of samples ("reverse-phase"). In this talk, we will attempt to place RPPAs in the broader context of other protein assays. Given this background, we will then describe issues we have encountered in modeling this data, and describe some of the tools we have developed for this purpose.

  • The address information is for the authors that have a + after their name.
  • Authors who are presenting talks have a * after their name.

Back to the full JSM 2007 program

JSM 2007 For information, contact jsm@amstat.org or phone (888) 231-3473. If you have questions about the Continuing Education program, please contact the Education Department.
Revised September, 2007