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Activity Number:
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488
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Type:
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Invited
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Date/Time:
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Thursday, August 2, 2007 : 8:30 AM to 10:20 AM
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Sponsor:
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Section on Government Statistics
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| Abstract - #307726 |
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Title:
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Adaptive Design and Analysis of Clinical Trials
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Author(s):
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Yu Shen*+ and Yi Cheng
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Companies:
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The University of Texas M.D. Anderson Cancer Center and Indiana University South Bend
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Address:
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1515 Holcombe Blvd, Unit 447, Houston, TX, 77030,
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Keywords:
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Clinical trial ; adaptive ; estimation ; inference
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Abstract:
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In this talk, we will describe statistical methodology in clinical trial designs that are adaptive, allowing flexibility for sample size determination, yet maintaining scientific validity. The methods will be applicable to various areas of health research, especially cancer clinical trials. Adaptive clinical trials continually update the design using cumulative information. Two types of adaptive sequential designs will be discussed within the framework of Bayesian and frequentist methods. The proposed methods can be used when outcomes are continuous, binary and time-to-event variables. Adaptive trials terminated early may exaggerate treatment benefits or harm in sequential designs. The investigation of bias adjusted estimators for various adaptive designs will be presented too.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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