JSM Preliminary Online Program
This is the preliminary program for the 2007 Joint Statistical Meetings in Salt Lake City, Utah.

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Activity Number: 49
Type: Invited
Date/Time: Sunday, July 29, 2007 : 4:00 PM to 5:50 PM
Sponsor: Section on Health Policy Statistics
Abstract - #307716
Title: Bivariate Normal Frailty Models for Multiple QOL Outcomes
Author(s): Andrea B. Troxel*+ and Denise A. Esserman
Companies: University of Pennsylvania and The University of North Carolina at Chapel Hill
Address: 423 Guardian Drive, School of Medicine, Philadelphia, PA, 19104,
Keywords: frailty models ; quality of life ; multivariate survival ; grouped data
Abstract:

This talk describes bivariate normal frailty models, with application to multiple, grouped, quality-of-life (QOL) events observed in clinical trials. Multiple QOL scales are assessed, with interval censoring, or grouping, due to the QOL assessment schedule. A bivariate normal frailty is introduced that incorporates dependence among the events while allowing different types of events to have different frailties (e.g., emotional vs. physical functioning scales). Extensions to joint analysis of QOL and survival outcomes will be discussed. Simulation results and a QOL example will be presented.

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Revised September, 2007