JSM 2005 Online Program

Abstract #302365

This is the preliminary program for the 2005 Joint Statistical Meetings in Minneapolis, Minnesota. Currently included in this program is the "technical" program, schedule of invited, topic contributed, regular contributed and poster sessions; Continuing Education courses (August 7-10, 2005); and Committee and Business Meetings. This on-line program will be updated frequently to reflect the most current revisions.

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Activity Number:	497
Type:	Invited
Date/Time:	Thursday, August 11, 2005 : 10:30 AM to 12:20 PM
Sponsor:	IMS
Abstract - #302365
Title:	The Genomes of Recombinant Inbred Lines
Author(s):	Karl W. Broman*+
Companies:	Johns Hopkins University
Address:	Department of Biostatistics, Baltimore, MD, 21205,
Keywords:	absorption probabilities ; Markov chains ; genetics ; crossover interference ; applied probability ; inbreeding
Abstract:	Recombinant inbred lines (RILs) are formed by crossing two inbred strains (e.g., of mice), followed by repeated sibling mating (or, in some plants, selfing) to produce a new inbred line whose genome is a mosaic of the genomes of the initial strains. RILs can be powerful tools for genetic mapping. Recently, members of the Complex Trait Consortium have proposed the development of a large panel of eight-way RILs in the mouse, derived from eight genetically diverse parental strains. The use of such eight-way RILs will require a detailed understanding of the relationship between alleles at linked loci on an RI chromosome. We have extended the work of Haldane and Waddington (1931) on two-way RILs and describe the map expansion, clustering of breakpoints, and other features of the genomes of multiway RILs as a function of the level of crossover interference in meiosis. The problem concerns the absorption probabilities of a Markov chain with a very large number of states.

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