JSM 2005 - Toronto

Abstract #304455

This is the preliminary program for the 2005 Joint Statistical Meetings in Minneapolis, Minnesota. Currently included in this program is the "technical" program, schedule of invited, topic contributed, regular contributed and poster sessions; Continuing Education courses (August 7-10, 2005); and Committee and Business Meetings. This on-line program will be updated frequently to reflect the most current revisions.

To View the Program:
You may choose to view all activities of the program or just parts of it at any one time. All activities are arranged by date and time.



The views expressed here are those of the individual authors
and not necessarily those of the ASA or its board, officers, or staff.

The Program has labeled the meeting rooms with "letters" preceding the name of the room, designating in which facility the room is located:

Minneapolis Convention Center = “MCC” Hilton Minneapolis Hotel = “H” Hyatt Regency Minneapolis = “HY”

Back to main JSM 2005 Program page
Legend: = Applied Session, = Theme Session, = Presenter
Activity Number: 449
Type: Contributed
Date/Time: Wednesday, August 10, 2005 : 2:00 PM to 3:50 PM
Sponsor: Biopharmaceutical Section
Abstract - #304455
Title: Estimation Following Adaptive Design
Author(s): Chengqing Wu*+ and Aiyi Liu and Kai F. Yu and James F. Troendle
Companies: National Institute of Child and Health & Human Development and National Institute of Child and Health & Human Development and National Institute of Child and Health & Human Development and National Institute of Child and Health & Human Development
Address: 6100 Executive BLVD 7B05, Rockville, MD, 20892, United States
Keywords: Adaptive design ; sample size re-estimation ; Whitehead estimator ; Rao-Blackwell estimator ; mean square error
Abstract:

In this paper, we investigate estimation of treatment efficacy after two-stage adaptive design. Based on the density of sufficient statistics, sample mean are shown to be maximum estimators, but biased. Two alternative estimators are proposed. One is bias-adjusted estimator suggested by Whitehead (1986a,b) in group sequential design. The other is unbiased estimator following the Rao-Blackwell approach. Performance of these estimators are evaluated numerically through bias and mean square error (MSE).

  • The address information is for the authors that have a + after their name.
  • Authors who are presenting talks have a * after their name.

Back to the full JSM 2005 program

JSM 2005 For information, contact jsm@amstat.org or phone (888) 231-3473. If you have questions about the Continuing Education program, please contact the Education Department.
Revised March 2005