JSM 2005 - Toronto

Abstract #303850

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Activity Number: 385
Type: Topic Contributed
Date/Time: Wednesday, August 10, 2005 : 10:30 AM to 12:20 PM
Sponsor: Section on Statistical Consulting
Abstract - #303850
Title: Genomic Screening in Family-based Association Testing
Author(s): Christoph Lange*+ and Kristel Van Steen
Companies: Harvard School of Public Health and Harvard School of Public Health
Address: 655 Huntngton Ave, Boston, MA, 02138, United States
Keywords: Genome-wide association studies ; FBAT
Abstract:

The Human Genome Project and its spinoffs, such as the Allele Frequency/Genotype Project or the Haplotype Map Project, are making it increasingly possible to disentangle the genetic basis of a given complex trait using genomewide association studies. The statistical challenge in analyzing such genomewide association studies stems from the severe multiple comparison problem that has to be dealt with. Standard multiple comparison methods are not likely to be successful in finding associations that achieve genomewide significance. Our proposed methodology for family-based association studies successfully deals with this issue, also in the context of genomewide screening. We provide lower bounds for the estimated power to detect the gene harboring and the disease susceptibility locus, which hold even in the presence of high-linkage disequilibrium. In addition, we argue that the proposed screening tools accommodate genomic control and impact the concept of haplotype-tagging SNPs.

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