JSM 2004 - Toronto

Abstract #302177

This is the preliminary program for the 2004 Joint Statistical Meetings in Toronto, Canada. Currently included in this program is the "technical" program, schedule of invited, topic contributed, regular contributed and poster sessions; Continuing Education courses (August 7-10, 2004); and Committee and Business Meetings. This on-line program will be updated frequently to reflect the most current revisions.

To View the Program:
You may choose to view all activities of the program or just parts of it at any one time. All activities are arranged by date and time.

The views expressed here are those of the individual authors
and not necessarily those of the ASA or its board, officers, or staff.

Back to main JSM 2004 Program page
Activity Number: 372
Type: Topic Contributed
Date/Time: Wednesday, August 11, 2004 : 2:00 PM to 3:50 PM
Sponsor: Biometrics Section
Abstract - #302177
Title: Adaptive Stagewise Designs in Clinical Trials
Author(s): Shelemyahu Zacks*+
Companies: Binghamton University
Address: Dept. of Math and Science, Binghamton, NY, 13902-6000,
Keywords: adaptive procedures ; search for optimal dosage ; cancer phase I clinical trials ; quantal response analysis ; Bayesian procedures ; randomized designs
Abstract:

Adaptive stagewise procedures are those which incorporate in the design of each stage all the information gathered in previous stages. In contrast with sequential procedures, there are no stopping rules. Adaptive stagewise designs are applied in different fields of treatments and data collection. We focus attention on cancer phase I clinical trials (CPICT), in which the toxicity of new drugs is tested. The objective in these trials is to find the Maximum Tolerated Dose (MTD), and give all patients this dose. We discuss parametric and nonparametric models relating the observed toxicity to the MTD. We discuss Bayesian and non-Bayesian procedures and their efficacy. Randomized play the winner procedures are compared with parametric Bayesian procedures.

  • The address information is for the authors that have a + after their name.
  • Authors who are presenting talks have a * after their name.

Back to the full JSM 2004 program

JSM 2004 For information, contact jsm@amstat.org or phone (888) 231-3473. If you have questions about the Continuing Education program, please contact the Education Department.
Revised March 2004