JSM 2004 - Toronto

Abstract #301987

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Activity Number: 157
Type: Contributed
Date/Time: Monday, August 9, 2004 : 2:00 PM to 3:50 PM
Sponsor: ENAR
Abstract - #301987
Title: Longitudinal Analysis of Predictors of Depressive Symptoms in Old Age with Adjustment for Heritability
Author(s): Amy L. Byers*+ and Marilyn Stolar and Heather G. Allore
Companies: Yale University and Yale University and Yale University
Address: Program on Aging, New Haven, CT, 06510,
Keywords: heritability ; genetic ; longitudinal data analysis ; psychosocial ; family studies ; depressive symptoms
Abstract:

We present a case study using a multilevel model for a longitudinal continuous outcome measure obtained from the USC Longitudinal Study of Generations. We examine the association between nongenetic intergenerational factors and depressive symptoms in aging parents (age 50 - 72) with adjustment for heritability. The outcome, parent's depressive symptoms, was measured by the Center for Epidemiologic Studies Depression scale (CESD). Both the outcome variable and predictor variables were measured at baseline (in 1985) with two waves of follow-up at years 3 and 6. The heritability of the phenotypic trait of depressive symptoms was found to be 8.6% (95% CI: 0 - 57%; p=0.71) using a multilevel mixed effects model for 230 families. In summary, heritability was found not to be an important covariate in the model. This study raises the possibility that depressive symptoms measured by the CESD are not heritable but are influenced by nongenetic factors.

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