JSM 2004 - Toronto

Abstract #301984

This is the preliminary program for the 2004 Joint Statistical Meetings in Toronto, Canada. Currently included in this program is the "technical" program, schedule of invited, topic contributed, regular contributed and poster sessions; Continuing Education courses (August 7-10, 2004); and Committee and Business Meetings. This on-line program will be updated frequently to reflect the most current revisions.

To View the Program:
You may choose to view all activities of the program or just parts of it at any one time. All activities are arranged by date and time.

The views expressed here are those of the individual authors
and not necessarily those of the ASA or its board, officers, or staff.

Back to main JSM 2004 Program page
Activity Number: 235
Type: Luncheons
Date/Time: Tuesday, August 10, 2004 : 12:30 PM to 1:50 PM
Sponsor: Biopharmaceutical Section
Abstract - #301984
Title: Issues in Choice and Analyses of Endpoints in Antiviral Drug Trials
Author(s): Victor G. De Gruttola*+
Companies: Harvard School of Public Health
Address: 665 Huntington Ave., Boston, MA, 02131,
Keywords: Antiretroviral Drug Trial ; study endpoints ; resistance mutations
Abstract:

Evaluation of efficacy of antiretroviral drugs is generally based on virological endpoints, such as viral load and development of resistance mutations. One issue that arises in defining such endpoints is how time series of viral load measurements can be summarized in a single metric. Common metrics include time to rebound and AUC. For analyses of the latter, nonparametric approaches may be preferable to standard analyses. To reduce viral genetic sequences to single metrics, resistance endpoints may be defined that are based on the drug options available to patients experiencing virological rebound. Such measures are necessary to evaluate the consequences of failing a therapy for patients' long-term prognoses.

  • The address information is for the authors that have a + after their name.
  • Authors who are presenting talks have a * after their name.

Back to the full JSM 2004 program

JSM 2004 For information, contact jsm@amstat.org or phone (888) 231-3473. If you have questions about the Continuing Education program, please contact the Education Department.
Revised March 2004