JSM 2004 - Toronto

Abstract #301795

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Activity Number: 43
Type: Topic Contributed
Date/Time: Sunday, August 8, 2004 : 4:00 PM to 5:50 PM
Sponsor: Biometrics Section
Abstract - #301795
Title: Gene Mapping in Recombinant Inbred Lines
Author(s): Karl W. Broman*+
Companies: Johns Hopkins University
Address: Bloomberg School of Public Health, Baltimore, MD, 21205,
Keywords: statistical genetics ; QTL-mapping ; linkage analysis ; mixed effects models
Abstract:

Recombinant inbred lines (RILs) are powerful tools for the genetic analysis of complex traits in model organisms, such as the mouse. RILs are developed by crossing two inbred strains followed by repeated sibling matings, in multiple independent lineages, to produce a new set of inbred strains whose genomes consist of a mosaic of the two parental strains' genomes. RILs are uniquely suited for the coordinated analysis of multiple invasive phenotypes, and for the study of gene-by-environment interactions, as one may phenotype multiple genetically identical individuals. The standard statistical methods for gene mapping in RILs are relatively rudimentary. We explore the use of mixed effects models for the genetic analysis of RILs.

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