JSM 2004 - Toronto

Abstract #301776

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Activity Number: 228
Type: Contributed
Date/Time: Tuesday, August 10, 2004 : 10:30 AM to 12:20 PM
Sponsor: Biometrics Section
Abstract - #301776
Title: Estimation of a Weibull PHM with Time-dependant Stochastic Covariates from Incomplete Data Using a Variant of the ECME Algorithm
Author(s): Dragan Banjevic*+
Companies: University of Toronto
Address: 5 King's College Rd., Toronto, ON, M5S 3G8, Canada
Keywords: proportional hazards ; Markov process ; stochastic covariates ; incomplete data ; EM algorithm ; reliability
Abstract:

A method for estimation of parameters of a proportional-hazards model (PHM) with time-dependent stochastic covariates from incomplete covariate data is discussed. It is assumed that the failure-time process and the covariate process follow a nonhomogeneous multidimensional Markov process. A variant of the ECME algorithm of Liu and Rubin for simultaneous estimation of both the PHM parameters and Markov process transition rates is considered. Convenient recursive formulas are derived necessary to perform E-step in the calculation, as well as to calculate the observed information matrix, required for direct minimization in Newton-Raphson method and for estimation of the standard errors. The recursive formulas also include solution to an extremely important problem in the calculation, that is, to the scaling of very small probabilities and expectations that may cause underflow in the computation of the likelihood function. The method is applied to real data from industry obtained from equipment condition monitoring and associated failure times.


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