JSM 2004 - Toronto

Abstract #301201

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Activity Number: 166
Type: Contributed
Date/Time: Monday, August 9, 2004 : 2:00 PM to 3:50 PM
Sponsor: Section on Statistics in Epidemiology
Abstract - #301201
Title: Apo-E Genotypes and Cardiovascular Diseases: A Sensitivity Study
Author(s): Mark E. Glickman*+
Companies: Boston University
Address: EN Rogers Mem. Hospital (152), Bldg. 70, Bedford, MA, 01730,
Keywords:
Abstract:

The Apo-E gene, a gene that produces proteins which help to regulate lipid levels in the bloodstream, is of interest in the study of cardiovascular diseases. An approach to making inferences about the genetic effects of the Apo-E gene has been developed by Glickman and Gagnon (2002). The framework describes the role of genetic and risk factors on the onset ages of multiple diseases, and accounts for missing data due to censoring, and the possibility that an individual was censored for reasons related to the diseases of interest. We apply an extension to this framework to the original cohort of the Framingham Heart Study for measuring the effects of different Apo-E genotypes on the onset age of various cardiovascular disease events. In particular, we compare the fit of univariate vs. multivariate onset age components to the model, whether to incorporate health covariates measured at baseline or at a point later in the study, and whether to assume a heritability model for Apo-E genotype frequencies. The results of the best-fitting model are presented.

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