JSM 2004 - Toronto

Abstract #301027

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Activity Number: 219
Type: Contributed
Date/Time: Tuesday, August 10, 2004 : 10:30 AM to 12:20 PM
Sponsor: WNAR
Abstract - #301027
Title: SCPRT: A Sequential Procedure Giving Another Reason to Stop a Trial Early
Author(s): Xiaoping Xiong*+ and Ming T. Tan and James Boyett
Companies: St. Jude Children's Research Hospital and University of Maryland and Medicine and St. Jude Children's Research Hospital
Address: 332 N. Lauderdale St. , Memphis, TN, 38105,
Keywords: clinical trial ; design ; sequential test
Abstract:

A sequential procedure for clinical trial is a test design that allows early stopping and satisfies given significance level and power. By this convention, many different sequential test designs are available for a same requirement. Reversely, a same set of observed data can be interpreted as outcomes of different sequential designs with different significance levels and powers. With a same set of observed data, one may conclude a test significant by one sequential design, and conclude the test insignificant by another sequential test design; this phenomenon may lead one to ask a question whether application of sequential tests is rational. Withstanding this challenge, the sequential conditional probability ratio test (SCPRT) is a class of sequential test designs with property that a conclusion made at early stopping is unlikely to be reversed if the trial had continued to the planned end. This property gives us another reason to stop a trial early: if the trial were not stopped as it should, then adding more data and continuing the trial (by the planned end) will not change the conclusion. We will introduce SCPRT procedures for different distributions and various applications.

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