JSM 2004 Online Program

Abstract #301007

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Activity Number:	339
Type:	Contributed
Date/Time:	Wednesday, August 11, 2004 : 10:30 AM to 12:20 PM
Sponsor:	Biopharmaceutical Section
Abstract - #301007
Title:	A Comparison of Methods for the Joint Evaluation of Incidence and Severity
Author(s):	Xiaoming Li*+ and Devan V. Mehrotra
Companies:	Merck & Co., Inc. and Merck & Co., Inc.
Address:	UN-A102, Blue Bell, PA, 19422,
Keywords:	joint evaluation ; incidence ; severity
Abstract:	In randomized comparative clinical trials, joint evaluation of incidence and severity is often of interest. For example, two vaccines could be compared with respect to their relative ability to prevent the disease in question (e.g., chicken pox), along with the relative severity of the disease among those infected. We will compare few statistical methods for the joint evaluation of incidence and severity. The methods include Lachenbruch's "two-part" model, O'Brien's method, Fisher's combined p value method, and Simes's method. An illustrative example and simulation results will be provided to support some recommendations.

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