JSM 2004 Online Program

Abstract #300674

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Activity Number:	274
Type:	Contributed
Date/Time:	Tuesday, August 10, 2004 : 2:00 PM to 3:50 PM
Sponsor:	Biopharmaceutical Section
Abstract - #300674
Title:	Standardization, False Positives, and False Negatives in Microarray Gene Expression
Author(s):	Borko D. Jovanovic*+ and Irene B. Helenowski and Marlos A.G. Viana and Alfred W. Rademaker and Raymond C. Bergan
Companies:	Northwestern University Medical School and Northwestern University and University of Illinois, Chicago and Northwestern University Medical School and Northwestern University Medical School
Address:	680 N. Lake Shore Dr., Suite 1102, Chicago, IL, 60611,
Keywords:	Monte Carlo ; simulations ; log-normal ; outliers
Abstract:	We compare error rates stemming from using ratio (1/k)< R=Y/X< k in gene screening for several commonly used methods for standardizing gene expression in microarrays. The underlying distribution of gene expression is assummed to be log-normal, with mean and SD taken from a published study. Computer simulations are run in S-PLUS and R.

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