JSM 2004 Online Program

Abstract #300640

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Activity Number:	305
Type:	Contributed
Date/Time:	Wednesday, August 11, 2004 : 8:30 AM to 10:20 AM
Sponsor:	Biopharmaceutical Section
Abstract - #300640
Title:	Max-min Confidence Intervals for Differences between Treatments and Control for Monotone Dose-response Curves
Author(s):	Jianan Peng*+ and Charles Lee and Lin Liu
Companies:	Acadia University and Memorial University of Newfoundland and University of California, San Diego
Address:	12 University Avenue, Wolfville, NS, B4P 2R6, Canada
Keywords:	simultaneous confidence intervals ; Dunnett's procedure
Abstract:	The comparison of increasing doses of a drug to a zero dose control is of interest in medical and toxicological studies. Usually the dose-response curve is monotone. A simple procedure that modifies Dunnett's procedure is proposed to construct simultaneous confidence intervals for differences between each treatment and the control by utilizing the ordering of the means. The procedure compares well with its predecessor.

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