JSM 2004 - Toronto

Abstract #300464

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Activity Number: 112
Type: Contributed
Date/Time: Monday, August 9, 2004 : 10:30 AM to 12:20 PM
Sponsor: Biopharmaceutical Section
Abstract - #300464
Title: Estimation of Lag Time between Onset of and Death from an Occult Tumor
Author(s): Hojin Moon*+ and Hongshik Ahn and Ralph L. Kodell
Companies: U.S. Food and Drug Administration and SUNY, Stony Brook and U.S. Food and Drug Administration
Address: National Center for Toxicological Researc, Div of Biometry and Risk Assessment, Jefferson, AR, 72079,
Keywords: bioassay ; cause of death ; lag time ; likelihood ; tumor lethality
Abstract:

A new statistical procedure for estimating the lag time between onset of and death from an occult tumor is proposed for data without cause-of-death information for each animal or context of observation for each tumor. The proposed method is based on a nonparametric model. Tumor lethality information required for the lag-time estimation is obtained using statistical methods. In the proposed method, numbers of fatal and incidental tumors are statistically imputed by using the estimates of the tumor onset function and tumor-specific survival function obtained from closed form solutions for nonparametric maximum-likelihood estimators under explicit and implicit inequality constraints. The proposed method is illustrated using a real dataset. The accuracy of the estimation of lag time is evaluated via a Monte Carlo simulation study.

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