JSM 2004 - Toronto

Abstract #300250

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Activity Number: 169
Type: Invited
Date/Time: Tuesday, August 10, 2004 : 8:30 AM to 10:20 AM
Sponsor: WNAR
Abstract - #300250
Title: Robust Tests for Recurrent Events Occurring over Multiple Treatment Periods
Author(s): Richard J. Cook*+ and Wei Wei and Grace Y. Yi
Companies: University of Waterloo and University of Michigan and University of Waterloo
Address: 200 University Ave. West, Waterloo, ON, N2L 3G1, Canada
Keywords: recurrent events ; marginal rate ; conditioning ; robustness ; pseudo-score test
Abstract:

Robust methods for the analysis of recurrent events have been developed based on Poisson estimating functions. We describe an alternative robust approach suitable for settings in which recurrent events occur over multiple treatment periods and treatment comparisons are of primary interest. The approach is motivated by a "working" mixed Poisson model in which suitable conditioning can eliminate the subject-specific effects. A robust variance is derived for the resulting pseudo-score statistic. The relative efficiency of the conditional analyses versus a marginal analysis is examined, and the robustness of the new test is demonstrated through simulations. The method is illustrated by application to data from an asthma trial.

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