JSM 2004 Online Program

Abstract #300083

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Activity Number:	419
Type:	Invited
Date/Time:	Thursday, August 12, 2004 : 10:30 AM to 12:20 PM
Sponsor:	Biopharmaceutical Section
Abstract - #300083
Title:	Death by Data Analysis? The Demise of 2D-Gel Proteomics
Author(s):	Bert Gunter*+
Companies:	Merck & Co., Inc.
Address:	PO Box 2000, Rahway, NJ, 07065,
Keywords:	proteomics ; quality control ; biotechnology ; image analysis
Abstract:	Modern biotechnology has made fantastic advances that yield very rich data--witness gene chips, medical imaging, and HPLC-coupled mass spectrometry. Unfortunately, quality control to remove or compensate for the many confounding systematic sources of variability in these complex measurement processes has often been lacking. An inadequate understanding of variability has led to primitive or just plain wrong data analyses and poor (but often glitzy!) data analysis software. We discuss these issues in the context of 2-D gel proteomics, a once promising technology that seems to be dying due to, among other reasons, the inability to overcome difficult fundamental quality control and data analysis issues.

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