Abstract #301854

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JSM 2002 Abstract #301854
Activity Number: 364
Type: Contributed
Date/Time: Wednesday, August 14, 2002 : 2:00 PM to 3:50 PM
Sponsor: Biopharmaceutical Section*
Abstract - #301854
Title: Spatial Pattern ANOVA in Neuroanatomy
Author(s): Carrie Wager*+ and Brent Coull and Nicholas Lange
Affiliation(s): Harvard School of Public Health
Address: 655 Huntington Avenue, Boston, Massachusetts, 02115, USA
Keywords: Generalized linear mixed model ; Inhomogeneous Poisson ; Kriging ; Voronoi Tiling ; Eigendecomposition ; Replicated Spatial Point Patterns
Abstract:

We present a case study of a designed experiment involving spatial patterns of neuronal activation in response to psychotropic drug treatments. The activation of each neuron is driven by several stochastic mechanisms, including regional targetting by a drug, subject susceptibility to treatment, and interaction with other neurons. To compare activation for different drugs across distinct brain regions, we develop a general hierarchical model for analyzing salient features of the underlying point process. Embedded in this model, we explore several strategies for for modelling a single point pattern, beginning with simple Poisson counting, and ending with intensity kriging, a method we've recently devised for smoothly predicting the underlying intensity using a loglinear mixed mixed model formulation.

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Revised March 2002