Abstract #301839


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JSM 2002 Abstract #301839
Activity Number: 347
Type: Topic Contributed
Date/Time: Wednesday, August 14, 2002 : 2:00 PM to 3:50 PM
Sponsor: Section on Statistics in Epidemiology*
Abstract - #301839
Title: Longitudinal Categorical Data and Likelihood Inference
Author(s): Patrick Heagerty*+
Affiliation(s): University of Washington
Address: Box 357232, Seattle, Washington, 98185, USA
Keywords:
Abstract:

One common goal of a longitudinal study is to compare two or more groups with respect to their average response at various follow-up times. This talk will discuss flexible likelihood-based regression methods for the analysis of serial categorical data that can be used to estimate response profiles. The approach is called a "marginalized transition model" (Heagerty 2002, Biometrics) since the likelihood is constructed using two assumptions: a marginal mean regression model that characterizes systematic variation in the average response as a function of covariates (including group and time); and a Markov dependence model, or transition model, that describes serial correlation within an individual. One advantage to a likelihood approach is that a profile likelihood can guide selection of appropriate covariate transformations that may facilitate parsimonious models for group differences over time.


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