Abstract #301451

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JSM 2002 Abstract #301451
Activity Number: 289
Type: Contributed
Date/Time: Wednesday, August 14, 2002 : 8:30 AM to 10:20 AM
Sponsor: Biometrics Section*
Abstract - #301451
Title: Clustering of Phenotype Items for Simpler Inheritance
Author(s): Steven Buyske*+
Affiliation(s): Rutgers University
Address: Hill Center, 110 Frelinghuysen Rd, Piscataway, New Jersey, 08854, United States
Keywords: complex traits ; genetics ; linkage ; cluster analysis
Abstract:

Complex behavioral traits such as schizophrenia and autism do not inherit in a simple Mendelian fashion, so that genetic mapping of susceptibility loci has been a frustrating exercise. In contrast, mapping simple Mendelian traits is a straightforward, if laborious, procedure.

There is evidence that at least some behavioral disorders may actually be the conjunction of multiple phenotypes. These phenotypes should be genetically simpler. We show how the genetic segregation patterns, by familiy, of phenotype item information can be used to cluster items into genetically simpler phenotypes. These synthetic phenotypes could lead to greater power in genetic linkage studies. Results are shown for simulated data.

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Revised March 2002