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Activity Number:
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421
- Contributed Poster Presentations: Health Policy Statistics Section
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Type:
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Contributed
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Date/Time:
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Tuesday, August 1, 2017 : 2:00 PM to 3:50 PM
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Sponsor:
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Health Policy Statistics Section
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Abstract #323847
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Title:
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Evidence Collection and Evaluation on Acrolein Biomarkers in Urine Resulting from Exposure to Tobacco and Non-Tobacco Products
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Author(s):
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Juan Vivar* and Qian Li and Eric Backlund and Derick Rivers
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Companies:
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Food and Drug Administration, Center for Tobacco Products and Food and Drug Administration and Food and Drug Administration, Center for Tobacco Products and Food and Drug Administration, Center for Tobacco Products
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Keywords:
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Acrolein biomarkers ;
tobacco products ;
health effects ;
systematic review
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Abstract:
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Acrolein, a respiratory and cardiovascular toxicant, is listed by FDA as a harmful and potentially harmful constituent in tobacco products. The goal of this project was to understand the association of acrolein biomarkers as a biomarker of risk in health effects and as exposure biomarkers in users of tobacco products and non-users. We conducted a systematic literature review on acrolein metabolites in urine as biomarkers of acrolein exposure in humans or animals. We searched six commonly used bibliographical databases as well as other databases. Then, we classified the literature into categories based on tobacco use and study subjects. We further grouped the search results by acrolein sources and study types. The information from each group will be synthesized and evaluated collectively to support the biomarker information. We identified 87 papers to assess biomarkers on differentiating tobacco users from non-users; information on dose-response relationship; and association with disease. We will share our experience in searching, extraction, and synthesis of the information, as well as the conclusions.
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Authors who are presenting talks have a * after their name.
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