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Abstract:
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In this talk, some statistical issues and methods arise in the analysis of data from Alzheimer's disease studies will be discussed. One is in the area of screening patients for the risk of developing Alzheimer's disease with a 40-item test by the standardized University of Pennsylvania Smell Identification Test (UPSIT)of olfactory function, which involves the issues of item selection and assessment. Another area to be discussed is on the analysis of health-related quality of life data that arise from Alzheimer's disease studies, in which patients' mental and physical conditions are measured over their follow-up periods and the resulting data are often complicated by subject-specific measurement times and possible terminal events associated with outcome variables.
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