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Monday, 08/02/2010
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To Adjust or Not to Adjust?: Simple vs. Adaptive/Forced Randomization
Yuko Y. Palesch, Medical University of South Carolina
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Designing Experiments for Biopharmaceutical Process Development
Julia O'Neill, Merck & Co., Inc.
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An Active Approach to Statistical Inference Using Randomiztion Methods
Todd Swanson, Hope College; Nathan Tintle, Hope College; Jill VanderStoep, Hope College; Vicki-Lynn Holmes, Hope College; Brooke Quisenberry, Hope College
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Adaptive Factorial Designs for Combination Therapy in Oncology
Donald Arthur Berry, MD Anderson Cancer Center
9:15 AM
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Probability in Decline
Dean Michael Brooks, Ekaros Analytical Inc.
9:55 AM
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Constrained Randomization Within Group-Randomized Trials: Implications for Comparative Effectiveness Research
Paul J. Nietert, Medical University of South Carolina; Ruth G. Jenkins, Medical University of South Carolina; Lynne S. Nemeth, Medical University of South Carolina; Andrea M. Wessell, Medical University of South Carolina; Peter M. Miller, Medical University of South Carolina; Steven M. Ornstein, Medical University of South Carolina
11:05 AM
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Hypothesis Testing of Treatment Policies in Two-Stage Randomization Designs
Xiang Guo, sanofi-aventis (China); Anastasios Tsiatis, North Carolina State University
2:30 PM
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Tuesday, 08/03/2010
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Design, Implementation, and Results for a Bayesian Adaptive Randomization Trial for Targeted Therapy in Lung Cancer
Suyu Liu, MD Anderson Cancer Center; J. Jack Lee, MD Anderson Cancer Center
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Permutation Tests for Random Effects in Linear Mixed Models
Oliver Lee, University of Michigan
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Propensity Score Matching in Randomized Clinical Trials
Zhenzhen Xu, University of Michigan; John David Kalbfleisch, University of Michigan
9:20 AM
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Sample Size Re-estimation in Crossover Trials
Adina Soaita, Pfizer Inc.; Byron Jones, Pfizer Inc.; Jerry J. Weaver, Pfizer Inc.
10:35 AM
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Developing a Randomization Protocol in a Community-Partnered Participatory Research Project to Reduce the Burden of Depression
Thomas R. Belin, University of California, Los Angeles; Susan E. Stockdale, University of California, Los Angeles; Lingqi Tang, University of California, Los Angeles; Felica Jones, Healthy African American Families II; Andrea Jones, Healthy African American Families II; Aziza Wright, Healthy African American Families II; Judy Perlman, RAND Corporation; Esmeralda Ramos, University of California, Los Angeles; Loretta Jones, Healthy African American Families II; Elizabeth Dixon, Queenscare; Kenneth B. Wells, University of California, Los Angeles
10:50 AM
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Applying Covariate-Adjusted, Response-Adaptive Randomization to Medical Device Studies
Thomas E. Gwise, FDA; Gene Anthony Pennello, FDA
10:55 AM
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I-SPY2: Identifying Biomarker Signatures for Therapeutic Agents in Neoadjuvant Breast Cancer
Donald Arthur Berry, MD Anderson Cancer Center; Kyle Wathen, MD Anderson Cancer Center; Nebiyou Bekele, MD Anderson Cancer Center; Laura Esserman, University of California, San Francisco
11:35 AM
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Wednesday, 08/04/2010
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Optimal G-Estimation Mediation Analyses Under Departure from Sequential Ignorability
Rongmei Zhang, University of Pennsylvania; Marshall M. Joffe, University of Pennsylvania; Thomas R. Ten Have, University of Pennsylvania School of Medicine
9:15 AM
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The Advantageous Adaptive Randomization in Clinical Trials
Bob Zhong, Johnson & Johnson
10:35 AM
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A Comparison of the Results of Intent-to-Treat, per-Protocol, and g-Estimation in the Presence of Nonrandom Treatment Changes in a Time-to-Event Noninferiority Trial
Yutaka Matsuyama, The University of Tokyo
10:55 AM
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A Theory for Testing Hypotheses Under Covariate-Adaptive Randomization
Jun Shao, University of Wisconsin-Madison; Xinxin Yu, University of Wisconsin-Madison; Bob Zhong, Johnson & Johnson
10:55 AM
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Covariate-Adjusted Response-Adaptive Randomization Design with Survival Responses
Hongjian Zhu, University of Virginia; Feifang Hu, University of Virginia
11:15 AM
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Statistical Testing in Clinical Trial with Covariate Adaptive Randomization
H.M. James Hung, FDA; Sue-Jane Wang, FDA
2:05 PM
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Properties of Re-Randomization Tests in Clinical Trials with Adaptive Randomization
Stephen Lake, Genzyme Corporation; Cyrus R. Mehta, Cytel Inc.; L. J. Wei, Harvard University
2:35 PM
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Predictive Probability Approach for the Design and Analysis of Response and Toxicity Data in Cancer Clinical Trials
J. Jack Lee, MD Anderson Cancer Center; Guosheng Yin, The University of Hong Kong; Nan Chen, M D Anderson Cancer Center
2:55 PM
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Weighted Randomization Test for Multi-Arm Randomized Clinical Trials
Feifang Hu, University of Virginia
3:05 PM
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Expected Frequency of Allowed Forced Allocations in a Multicenter Clinical Trial
Suvajit Samanta, Merck Research Laboratories; Olga Kuznetsova, Merck Research Laboratories
3:20 PM
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