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Monday, 08/02/2010
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Cancer Marker Identification via Penalized Integrative Analysis
Shuangge Ma, Yale University
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Statistical Considerations on Validating Microarray Platform in Clinical Development
Guang (Gary) Chen, Merck & Co., Inc.; Christopher Ramsborg, Merck & Co., Inc.; Yue Wang, Merck & Co., Inc.; Miho Kibukawa, Merck & Co., Inc.; Joel A. Klappenbach, Merck & Co., Inc.
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Doing Better Than Average: Tailored Therapeutics in Drug Development
Stan Young, National Institute for Statistical Science; Stephen J. Ruberg, Eli Lilly and Company; Frank Rockhold, GlaxoSmithKline; Sue-Jane Wang, FDA; Stephen Senn, University of Glasgow
1:00 AM
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Risk Predictions from Genomewide Association Data
Hongyu Zhao, Yale University; Jia Kang, Yale University; Ruiyan Luo, Yale University; Judy Cho, Yale University
8:35 AM
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Future Directions in the Analysis of Genomic Data
Nancy Zhang, Stanford University; Terence (Terry) Paul Speed, Walter & Eliza Hall Institute of Medical Research
8:35 AM
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Discriminating Between Microbial Populations
Frederick A. Matsen, Fred Hutchinson Cancer Research Center ; Steven N. Evans, University of California, Berkeley
9:35 AM
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Large-Margin, Single-Path Hierarchical Classification with a General Loss
Lingzhou Xue, University of Minnesota; Xiaotong Shen, University of Minnesota
9:55 AM
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Joint Inference of Sparse Network and Genetic Association in Genetical Genomics Studies
Hongzhe Li, University of Pennsylvania
11:00 AM
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A Case Study of Using a Genomic Assay to Predict the Benefit of Chemotherapy in Treating Breast Cancer: Testing, Prediction, and Study Planning
William E. Barlow, Cancer Research and Biostatistics (CRAB); Carl Yoshizawa, Genomic Health, Inc.
11:00 AM
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Learning Regulatory Network from Multiple Genomics Array Data
Pei Wang, Fred Hutchinson Cancer Research Center; Jie Peng, University of California, Davis
11:25 AM
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Statistical Analysis of Somatic Changes in Cancer Genomics
Giovanni Parmigiani, Harvard University
11:25 AM
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A Stochastic Partitioning Method to Associate High-Dimensional Data Sets
Mahlet G. Tadesse, Georgetown University; Stefano Monni, Weill Cornell Medical College
11:35 AM
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Some Statistical Issues in the Analysis of High-Throughput Sequencing Data
Margaret Taub, The Johns Hopkins University
2:05 PM
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Modeling with Pairwise Comparisons
Jeffrey Leek, Johns Hopkins Bloomberg School of Public Health; Leslie Cope, The Johns Hopkins University; Donald Geman, The Johns Hopkins University; Giovanni Parmigiani, Harvard University
2:05 PM
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Integration of Genomic Data to Infer the Genetic Architecture of Complex Phenotypes
Sayan Mukherjee, Duke University; Qing Xiong, Duke University; Terrence Furey, Duke University
2:30 PM
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Semiparametric Bayesian Analysis of High-Throughput Array CGH Data
Subharup Guha, University of Missouri
2:35 PM
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An Orthogonal Transformed Aggregation Statistic to Test Gene Regulation with Prespecified Gene Sets or Pathways
Shuyan (Sabrina) Wan, Merck Research Laboratories; Nanshi Sha, Columbia University; Peggy Wong, Merck Research Laboratories
2:50 PM
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Overcoming the Winner's Curse to Identify Biomarkers with Clinical Relevance in Drug Development
Lei Shen, Eli Lilly and Company; Haoda Fu, Eli Lilly and Company
3:20 PM
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Tuesday, 08/03/2010
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A Decision-Theoretic Approach to Gene Set Analysis
Simina Maria Boca, Johns Hopkins Bloomberg School of Public Health; Hector Corrada Bravo, Johns Hopkins Bloomberg School of Public Health; Giovanni Parmigiani, Harvard University; Jeffrey Leek, Johns Hopkins Bloomberg School of Public Health
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Likelihood-Based Evaluation of Normalization Methods
Sadhvi Khanna, The University of Arizona
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An Efficient Method for Estimating Chromosome Copy Number of Variations and Its Theoretical Properties
Yue Selena Niu, The University of Arizona; Heping Zhang, Yale University
9:00 AM
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Challenges in Predicting Risk of Women Diseases Using Genomic Data
Mariza De Andrade, Mayo Clinic
11:55 AM
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Detection of Parent-of-Origin Effects for Quantitative Traits in Complete and Incomplete Nuclear Families with Multiple Children
Feng He, The University of Hong Kong; Wing Kam Fung, The University of Hong Kong; Yue-Qing Hu, Nanjing Medical University; Ji-Yuan Zhou, Southern Medical University
2:20 PM
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Wednesday, 08/04/2010
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Bayesian Methods in Genomics: Searching for Unity in Diverse Data Sources
Bhramar Mukherjee, University of Michigan; Debashis Ghosh, Pennsylvania State University
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Genomics in the Pharmaceutical Industry: Where Is It Headed?
Dhammika Amaratunga, Johnson & Johnson; James Colaianne, Johnson & Johnson
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Statistics, Technology, Epigenomics, and Our Future
Rebecca W. Doerge, Purdue University; Paul Auer, Purdue University
10:35 AM
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Novel Signal Processing-Based Methods for the Detection of Copy Number Changes in Human DNA
Catherine Stamoulis, Harvard Medical School; Rebecca Betensky, Harvard School of Public Health
2:05 PM
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A Homogenous Compound Poisson Change Point Model Approach for the Analysis of CNVs in Genomic Data
Jie Chen, University of Missouri-Kansas City; Ayten Yigiter, Hacettepe University; Hong-Wen Deng, University of Missouri-Kansas City
2:20 PM
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Efficient Exploration of Multiple ChIP-seq and ChIP-chip Data Sets
Hongkai Ji, The Johns Hopkins University
2:35 PM
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Clustering with Exclusion Zones: Genomic Applications
Mark Segal, University of California, San Francisco
3:05 PM
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Critiquing Bioinformatics Resources When ID Mapping Is Needed to Integrate Genomic and Proteomic Studies
Roger Day, University of Pittsburgh; Kevin McDade, University of Pittsburgh; Uma Chandran, University of Pittsburgh; Alex Lisovich, University of Pittsburgh
3:20 PM
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Thursday, 08/05/2010
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Biomarkers in Clinical Trials in the Development of Biologics and Risk Assessment
Samir Lababidi, FDA
8:50 AM
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A New Procedure to Identify Neighborhoods of Adjacent SNPs That Show a Specific Biologically Meaningful Pattern of Associations with Multiple Clinical Endpoints
Stan Pounds, St. Jude Children's Research Hospital
8:55 AM
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Integrative Clustering of Multiple Genomic Data Types Using a Regularized Joint Latent Variable Model
Ronglai Shen, Memorial Sloan-Kettering Cancer Center; Adam B. Olshen, University of California, San Francisco; Sijian Wang, University of Wisconsin-Madison
9:00 AM
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A Penalized Matrix Decomposition, with Applications to Sparse Principal Components and Canonical Correlation Analysis
Daniela Witten, Stanford University; Rob Tibshirani, Stanford University; Trevor Hastie, Stanford University
9:25 AM
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P-Values or Prediction Errors: What Is the Name of the Game in Genomics?
Rafal Kustra, University of Toronto
9:35 AM
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Bayesian Joint Modeling of Multiple Gene Networks and Diverse Genomic Data to Identify Target Genes of a Transcription Factor
Peng Wei, The University of Texas School of Public Health; Wei Pan, University of Minnesota
9:55 AM
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A Robust Statistical Framework for eQTL Analysis
Mohamedou Sow, Samuel Lunenfeld Research Institute; Gilles Durrieu, University Bordeaux 1; Laurent Briollais, Samuel Lunenfeld Research Institute
10:50 AM
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Moments of Strings of DNA Bases
Robert J. Blodgett, FDA; Errol Strain, FDA
11:50 AM
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