This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.

Abstract Details

Activity Number: 338
Type: Topic Contributed
Date/Time: Tuesday, August 3, 2010 : 10:30 AM to 12:20 PM
Sponsor: Section on Nonparametric Statistics
Abstract - #309004
Title: Estimating the Effect of Covariates on Functional Shape
Author(s): Kert Viele*+ and Robin Cooper
Companies: University of Kentucky and University of Kentucky
Address: Department of Statistics, Lexington, KY, 40506-0027,
Keywords: Self-Modeling Regression ; Functional Data Analysis ; Synaptic Transmission
Abstract:

Self-Modeling regression (SEMOR) provides a parsimonious method for analyzing a set of functions which have a similar shape. The central challenges of SEMOR modeling are estimating the underlying shape function nonparametrically and then estimating the variation in the time axis across curves.

In synaptic transmission data, a nerve cell is repeatedly stimulated with electricity and the voltage is recorded over time. These datasets have been shown to be very closely modeled by a SEMOR structure.

In our talk we illustrate the effect of pharmacological interventions on synaptic transmission, including changes in the self-modeling coefficients and changes in the underlying shape function.


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