Sequential Diagnostic Trials with applications to non-inferiority studies
*Larry Tang, George Mason University Keywords: ROC curve, optimal ratio Evaluation and comparison of the accuracy of two diagnostic medical devices have been typically conducted using fixed sample designs with subjective sampling ratios between the case and the control. On the other hand, group sequential design as an alternative of the fixed sample design addresses both cost and ethical concerns in diagnostic trials. In addition, optimal sampling ratio may be an efficient choice to minimize the total required sample size and reduce the overall costs of diagnostic studies. In this talk, we provide a brief overview of recent development on group sequential design methods and optimal sampling ratios in medical diagnostics. We discuss the application of these design methods to non-inferiority studies.
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Key Dates
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April 30 - May 22, 2013
Invited Abstract Submission Open -
June 4, 2013
Online Registration Opens -
August 9 - August 23, 2013
Invited Abstract Editing -
August 23, 2013
Short Course materials due from Instructors -
August 26, 2013
Housing Deadline -
September 9, 2013
Cancellation Deadline and Registration Closes @ 11:59 pm EDT -
September 16 - September 18, 2013
Marriott Wardman Park, Washington, DC