TL15: Application of EMA Bioequivalence Guidelines (2010) in a Global Setting
*James Lee, Daiichi Sankyo Pharma Development *Yibin Wang, Daiichi Sankyo Pharma Development Keywords: The recently published EMA Bioequivalence Guidelines (2010) stipulates the application of fixed effect ANOVA models should be used when proving bioequivalence. In addition, the CHMP PK Working Party (2011) states that data not relevant to the treatment comparison of interest should be removed. This contrasts with the commonly applied approach where all available data is used within a mixed model. The issue is not only for BE studies, but potentially influential on DDI or TQT studies which are crossover designs with 3 or more treatments. This roundtable discussion proposes to compare the approaches presented in the EMA and FDA guidance (2003) documents when proving bioequivalence and the application of both within a global setting.
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Key Dates
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April 30 - May 22, 2013
Invited Abstract Submission Open -
June 4, 2013
Online Registration Opens -
August 9 - August 23, 2013
Invited Abstract Editing -
August 23, 2013
Short Course materials due from Instructors -
August 26, 2013
Housing Deadline -
September 9, 2013
Cancellation Deadline and Registration Closes @ 11:59 pm EDT -
September 16 - September 18, 2013
Marriott Wardman Park, Washington, DC