Inferiority Index and Margin in NI Trials with Binary Outcomes
View Presentation *George Y.H. Chi, Jassen Research and Development, L.L.C. Gary G. Koch, University of North Carolina at Chapel Hill, Biostatistics Department *Gary G. Koch, University of North Carolina at Chapel Hill, Biostatistics Department Keywords: Inferiority index, Bernoulli distributions, binary effect measures, NI margin, anti-bacterial drug trial The concept of an inferiority index was introduced in Li & Chi (2011). Under normal distributions, there is a function linking the index to the variance ratio and the scaled relative difference measure. The inverse function will map a given index and variance ratio to a margin which can then be used to define a NI hypothesis. A test statistic is derived which is asymptotically normal. This talk will present research results under Bernoulli distributions. It is shown that for each binary effect measure, one can derive the link function between the inferiority index, the control rate and the effect measure. Through these link functions, equivalent NI hypotheses may be defined for the binary effect measures. Corresponding test statistics are derived and their relative performance can then be meaningfully compared. Applications to anti-bacterial drug trials will be illustrated.
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Key Dates
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April 30 - May 22, 2013
Invited Abstract Submission Open -
June 4, 2013
Online Registration Opens -
August 9 - August 23, 2013
Invited Abstract Editing -
August 23, 2013
Short Course materials due from Instructors -
August 26, 2013
Housing Deadline -
September 9, 2013
Cancellation Deadline and Registration Closes @ 11:59 pm EDT -
September 16 - September 18, 2013
Marriott Wardman Park, Washington, DC