Flexible Statistical Methods for Early Clinical Trials
View Presentation *Yaning Wang, FDA Keywords: estimation, trial design, modelling, exposure-response The focus of early clinical trials is to learn rather than confirm. Therefore, the statistical methods for these trials should be driven by estimation instead of hypothesis testing. During the review process, various efficient methods have been applied by FDA and recommended to the sponsors for analyzing early trials and planning for later trials. These methods include straightforward responder analysis, Bayesian survival modelling, nonlinear mixed effect pharmacokinetic/pharmacodynamic modelling, mechanistic-based disease modelling, etc. The ultimate goal of these analyses is to learn about the exposure-response to aid in designing pivotal trials.
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Key Dates
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April 30 - May 22, 2013
Invited Abstract Submission Open -
June 4, 2013
Online Registration Opens -
August 9 - August 23, 2013
Invited Abstract Editing -
August 23, 2013
Short Course materials due from Instructors -
August 26, 2013
Housing Deadline -
September 9, 2013
Cancellation Deadline and Registration Closes @ 11:59 pm EDT -
September 16 - September 18, 2013
Marriott Wardman Park, Washington, DC