TL46: Ensuring Success in Mood Disorder Trials
Rosanne Lane, Janssen Research & Development, LLC  *Pilar Lim, Janssen Research & Development, LLC 

Keywords: placebo response, mood disorder, expectation bias

High placebo response rates have been a major source of difficulty in many mood disorder trials and their effects have been difficult to overcome in developing new compounds. This roundtable session will discuss the following questions: 1. What design strategies have been used to address high placebo response rates? 2. What approaches have been used to reduce investigator and subject expectation bias? 3. Have these designs and approaches been acceptable to regulatory authorities?